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Fel d 1 surface expression on plant-made eBioparticles combines potent immune activation and hypoallergenicity

By October 9, 2022March 10th, 2023No Comments

Allergen immunotherapy (AIT) still remains the only disease- modifying treatment for immunoglobulin E (IgE)-mediated allergies with proven sustained efficacy upon discontinuation of the treatment, provided it is administered regularly for at least 3 years. Aluminum salts still remain a common depot and adjuvant for subcutaneous AIT that moderately reduce allergenicity; however, the risk of severe allergic reactions persists, making careful updosing protocols necessary. These characteristics justify the need for shorter treatments with improved safety profiles.

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